GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1395 | 1 | rs4665958 | chr2:27443196 | SLC5A6 | chr2:27422459-27435071:- | -0.32 | -6.86 | 2.2E-11 | Blood metabolite levels |
| THCA | cis | rs6547741 | 1 | rs4666009 | chr2:27857992 | FNDC4 | chr2:27714751-27718126:- | -0.15 | -3.52 | 0.00047 | Oral cavity cancer |
| THCA | cis | rs4372836 | 1 | rs4666118 | chr2:28951698 | PPP1CB | chr2:28974612-29025805:+ | 0.17 | 4.14 | 4.03E-5 | Body mass index |
| THCA | cis | rs4372836 | 1 | rs4666118 | chr2:28951698 | TRMT61B | chr2:29072690-29093175:- | -0.51 | -10.2 | 3.13E-22 | Body mass index |
| THCA | cis | rs4372836 | 1 | rs4666119 | chr2:28975690 | PPP1CB | chr2:28974612-29025805:+ | 0.17 | 4.26 | 2.5E-5 | Body mass index |
| THCA | cis | rs4372836 | 1 | rs4666119 | chr2:28975690 | TRMT61B | chr2:29072690-29093175:- | -0.53 | -10.65 | 6.52E-24 | Body mass index |
| THCA | cis | rs5743030 | 1 | rs4667304 | chr2:190587103 | ASNSD1 | chr2:190526125-190535556:+ | -0.69 | -6.75 | 4.18E-11 | Subcutaneous adipose tissue |
| THCA | cis | rs13394619 | 1 | rs4669752 | chr2:11727988 | GREB1 | chr2:11674242-11782912:+ | 0.17 | 3.68 | 0.000259 | Endometriosis |
| THCA | cis | rs2243480 | 1 | rs466983 | chr7:65520496 | CCT6P1 | chr7:65216092-65228661:+ | 0.41 | 6.46 | 2.51E-10 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs466983 | chr7:65520496 | CRCP | chr7:65579805-65619551:+ | -0.29 | -4.49 | 9.03E-6 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs466983 | chr7:65520496 | RABGEF1 | chr7:66093890-66276446:+ | 0.57 | 7.05 | 6.23E-12 | Diabetic kidney disease |
| THCA | cis | rs4671400 | 1 | rs4671400 | chr2:61472632 | AHSA2 | chr2:61404553-61414058:+ | -0.17 | -4.07 | 5.6E-5 | 3-hydroxypropylmercapturic acid levels in smokers |
| THCA | cis | rs4671400 | 1 | rs4671400 | chr2:61472632 | C2orf74 | chr2:61372243-61391964:+ | 0.4 | 4.68 | 3.78E-6 | 3-hydroxypropylmercapturic acid levels in smokers |
| THCA | cis | rs4671458 | 1 | rs4671458 | chr2:63374063 | C2orf86 | chr2:63348537-63815851:- | -0.19 | -3.88 | 0.000119 | Subjective well-being |
| THCA | cis | rs4671458 | 1 | rs4671459 | chr2:63392872 | C2orf86 | chr2:63348537-63815851:- | -0.19 | -3.9 | 0.00011 | Subjective well-being |